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The only way to really know if your fatty liver disease is NASH is to get your liver tested to check for scarring (fibrosis). At your next appointment, ask your liver specialist about getting tested for NASH.

If you have been diagnosed with NASH with liver scarring, regular monitoring may be needed to check and see if the scarring has gotten worse. You can also ask your liver specialist about Rezdiffra to help treat NASH with liver scarring.

There are a few different types of tests available to measure liver scarring (fibrosis). Ask your liver specialist which option is best for you. They may recommend one or a combination of the following tests:

• Blood-based tests
• Imaging and scanning tests
• Liver biopsy

If left unmanaged, NASH can lead to even more serious conditions like cirrhosis (severe scarring), cancer, or liver transplant. But there are things you can do, like getting your scarring checked regularly and asking your liver specialist about Rezdiffra.

Rezdiffra is the first and only FDA-approved once-daily pill for adults used to treat NASH with liver scarring,* along with diet and exercise.

This indication is approved based on improvement of NASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

*Moderate to advanced liver scarring (fibrosis) without cirrhosis.

If you are an adult (18 years and older) who has been diagnosed with NASH with liver scarring,* Rezdiffra may be right for you. At your next appointment, ask your liver specialist about Rezdiffra.

*Moderate to advanced liver scarring (fibrosis) without cirrhosis.

Rezdiffra treats NASH with liver scarring* by working directly in the liver and reactivating liver cells, allowing your liver to reduce liver fat.

*Moderate to advanced liver scarring (fibrosis) without cirrhosis.

Your liver specialist is the best person to ask. Regular visits per your specialist’s recommendations can help assess the effect of Rezdiffra on your liver.

Rezdiffra is a pill that you take as prescribed, once a day, every day for as long as your liver specialist tells you to. You can take Rezdiffra with or without food.

Each person may respond differently to Rezdiffra. Speak with your liver specialist if you have questions regarding how long you’ll need to take Rezdiffra.

It’s important to stay on treatment for as long as your liver specialist tells you to. Here are some tips that can help:

• Take Rezdiffra every day with or without food
• Stay on therapy for as long as your liver specialist tells you to
• Fit Rezdiffra into your routine by setting reminders

Rezdiffra may cause serious side effects. Stop taking Rezdiffra and/or call your doctor if you develop symptoms of:

• Liver injury (1 case in clinical trials): including tiredness, nausea, vomiting, fever, rash, jaundice, or stomach pain/tenderness
• Gallstones or gallbladder/pancreas inflammation: including nausea, vomiting, fever, or stomach pain

Common side effects observed in studies include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation. See Important Safety Information below for complete list of side effects.

Diarrhea and nausea were the most common side effects. Both typically began early in treatment and were mild to moderate, lasting ~3 to 4 weeks.*

Diarrhea and nausea were the most common side effects that caused patients to stop taking Rezdiffra. Both typically began early in treatment and were mild to moderate lasting ~3 to 4 weeks. Talk to your liver specialist about other side effects of Rezdiffra and how to best manage them.^†

^†Should these problems not resolve or should they become worse, please contact your doctor.

Once you’re prescribed Rezdiffra, you’ll get your prescription through a specialty pharmacy in Madrigal’s distribution network or through the Madrigal Patient Support program.

A specialty pharmacy stocks medications and treatments that are not typically found at your local retail pharmacy. Specialty pharmacies are intended to be easy and convenient for you to work with and will ship your medication directly to you.

Madrigal Patient Support can help you:

• Navigate the specialty pharmacy and access your Rezdiffra prescription
• Verify your coverage for Rezdiffra should your insurance status change
• Connect you with copay support if needed
• Determine if you qualify to receive Rezdiffra free of charge if you have no insurance or are denied coverage

For more information, dial 1-877-219-7770, Monday-Friday, 8 AM-8 PM ET, or visit MadrigalPatientSupport.com.

If you feel like NASH is overwhelming, ask your liver specialist to recommend a local support group. You can also connect with an advocacy group dedicated to helping people with liver diseases, including NASH, such as the ones below.^‡

• The Global Liver Institute
• NASH kNOWledge
• The Fatty Liver Foundation