About Rezdiffra Rezdiffra is the FIRST AND ONLY
FDA-approved treatment for adults
with NASH with liver scarring,* along with diet and exercise.

*Moderate to advanced liver scarring (fibrosis) without cirrhosis.

About Rezdiffra

Rezdiffra is the FIRST AND ONLY FDA-approved treatment for adults with NASH with liver scarring,* along with diet and exercise.

*Moderate to advanced liver scarring (fibrosis)
without cirrhosis.

About Rezdiffra

A breakthrough treatment for adults with NASH with liver scarring.*

Rezdiffra is a prescription pill taken once per day and is the only medicine proven to help:

Reduce scarring
(fibrosis)

REDUCE NASH

Quick Tip:

Rezdiffra goes hand-in-hand with a healthy diet and appropriate exercise routine. Work with your liver specialist to determine what's right for you.

Reduction in scarring defined as improvement in fibrosis with no worsening of steatohepatitis (defined as no increase in score for ballooning, inflammation, or steatosis).

Defined as resolution of steatohepatitis (score of 0-1 for inflammation, 0 for ballooning and any value for steatosis) with no worsening of liver scarring.

Study Results

How Rezdiffra can help you

Rezdiffra was studied in a large clinical trial and showed significant results at 1 year§

Helps reduce liver scarring

1.5 to 2 times as many patients taking either 80 mg or 100 mg of Rezdiffra compared to placebo saw improvement in liver scarring

as many patients taking either 80 mg or 100 mg of Rezdiffra compared to placebo

Helps reduce NASH

2 to 3 times as many patients taking either 80 mg or 100 mg of Rezdiffra compared to placebo saw NASH resolution

as many patients taking either 80 mg or 100 mg of Rezdiffra compared to placebo

On average, liver enzymes appeared to be reduced in patients taking Rezdiffra compared to those taking placebo starting as early as 3 months through 1 year.§,‖

§Rezdiffra was assessed by 2 credible healthcare providers (A&B).

Improvement in liver scarring in patients taking Rezdiffra vs placebo:

  A: 28% (100 mg of Rezdiffra), 23% (80 mg of Rezdiffra) vs 15% ( placebo)

  B: 24% (100 mg of Rezdiffra), 23% (80 mg of Rezdiffra) vs 13% (placebo)

NASH resolution in patients taking Rezdiffra vs placebo:

  A: 36% (100 mg of Rezdiffra), 27% (80 mg of Rezdiffra) vs 13% (placebo)

  B: 24% (100 mg of Rezdiffra), 26% (80 mg of Rezdiffra) vs 9% (placebo)

How Rezdiffra works

Rezdiffra works right where you need it

Rezdiffra treats NASH with liver scarring* by:

Working directly in the liver

Rezdiffra is specially designed to target your liver.

Helping reduce liver fat

Rezdiffra reactivates liver cells, allowing your liver to reduce liver fat.

*Moderate to advanced liver scarring (fibrosis) without cirrhosis.

How do I know if Rezdiffra is working?

Your liver specialist is the best person to ask. Regular visits per your specialist’s recommendations can help assess the effect of Rezdiffra on your liver.

Starting Rezdiffra

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Important Safety Information and Indication

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Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

The most common side effects of Rezdiffra include:

diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of NASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.

Important Safety Information and Indication

Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

The most common side effects of Rezdiffra include:

diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of NASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.